Ecdy - More evidence/how to amplify it with your training
Posted: Sat Feb 21, 2009 5:17 pm
The evidence for ecdysterone working just keeps piling up. In case the Russian research of the 1960's, 70's and 80's didn't convince you, there are a few new ones that make things a little more difficult to ignore.
One of these studies appears in the journal "Phytomedicine". Researchers from the university of Szeged in Hungary write in the article that rats given ecdysteroids develop thicker muscle fibres. Here again we see the classic 5mg per kg dosing scheme, likely taken from the Russian literature.
It was this one though, that I refer to in the course and the connection to the PI3K pathway which I discuss. I further detail in The Blueprint how to amplify this growth mechanism with stretch position-overload movements:
American researchers (Rutgers University) also recently published results of a study in which rats got bigger muscle cells and became stronger after receiving 20-hydroxy-ecdysterone and turkesterone. [J Agric Food Chem. 2008 May 28;56(10):3532-7.], both of which are contained in generous amount in Kre-Anabolyn.
J. Agric. Food Chem., 56 (10), 3532?3537, 2008. 10.1021/jf073059z
Web Release Date: April 30, 2008
Copyright 2008 American Chemical Society
Phytoecdysteroids Increase Protein Synthesis in Skeletal Muscle Cells
Jonathan Gorelick-Feldman,*? David MacLean,? Nebojsa Ilic,? Alexander Poulev,? Mary Ann Lila,# Diana Cheng,# and Ilya Raskin?
Biotech Center, Cook College, Rutgers University, 59 Dudley Road, New Brunswick, New Jersey 08901;Hallett Center for Diabetes and Endocrinology, Brown Medical School, Providence, Rhode Island 02912; and Department of Natural Resources and Environmental Sciences, University ofIllinois, Urbana, Illinois 61801
Abstract:
Phytoecdysteroids, which are structurally similar or identical to insect molting hormones, produce a range of effects in mammals, including increasing growth and physical performance. To study the mechanism of action of phytoecdysteroids in mammalian tissue, an in vitro cellular assay of protein synthesis was developed. In C2C12 murine myotubes and human primary myotubes, phytoecdysteroids increased protein synthesis by up to 20%. In vivo, ecdysteroids increased rat grip strength. Ecdysteroid-containing plant extracts produced similar results. The effect was inhibited by a phosphoinositide kinase-3 inhibitor, which suggests a PI3K-mediated mechanism.
One of these studies appears in the journal "Phytomedicine". Researchers from the university of Szeged in Hungary write in the article that rats given ecdysteroids develop thicker muscle fibres. Here again we see the classic 5mg per kg dosing scheme, likely taken from the Russian literature.
It was this one though, that I refer to in the course and the connection to the PI3K pathway which I discuss. I further detail in The Blueprint how to amplify this growth mechanism with stretch position-overload movements:
American researchers (Rutgers University) also recently published results of a study in which rats got bigger muscle cells and became stronger after receiving 20-hydroxy-ecdysterone and turkesterone. [J Agric Food Chem. 2008 May 28;56(10):3532-7.], both of which are contained in generous amount in Kre-Anabolyn.
J. Agric. Food Chem., 56 (10), 3532?3537, 2008. 10.1021/jf073059z
Web Release Date: April 30, 2008
Copyright 2008 American Chemical Society
Phytoecdysteroids Increase Protein Synthesis in Skeletal Muscle Cells
Jonathan Gorelick-Feldman,*? David MacLean,? Nebojsa Ilic,? Alexander Poulev,? Mary Ann Lila,# Diana Cheng,# and Ilya Raskin?
Biotech Center, Cook College, Rutgers University, 59 Dudley Road, New Brunswick, New Jersey 08901;Hallett Center for Diabetes and Endocrinology, Brown Medical School, Providence, Rhode Island 02912; and Department of Natural Resources and Environmental Sciences, University ofIllinois, Urbana, Illinois 61801
Abstract:
Phytoecdysteroids, which are structurally similar or identical to insect molting hormones, produce a range of effects in mammals, including increasing growth and physical performance. To study the mechanism of action of phytoecdysteroids in mammalian tissue, an in vitro cellular assay of protein synthesis was developed. In C2C12 murine myotubes and human primary myotubes, phytoecdysteroids increased protein synthesis by up to 20%. In vivo, ecdysteroids increased rat grip strength. Ecdysteroid-containing plant extracts produced similar results. The effect was inhibited by a phosphoinositide kinase-3 inhibitor, which suggests a PI3K-mediated mechanism.
