I thought this was interesting. Does anyone have any experience using COQ10 or Ubiquinol as a lifting supplement?
https://www.ncbi.nlm.nih.gov/pubmed/12069109
Free Radic Res. 2002 Apr;36(4):445-53.
Cellular redox activity of coenzyme Q10: effect of CoQ10 supplementation on human skeletal muscle.
Linnane AW, Kopsidas G, Zhang C, Yarovaya N, Kovalenko S, Papakostopoulos P, Eastwood H, Graves S, Richardson M.
Source
Centre for Molecular Biology and Medicine, Epworth Medical Centre, Richmond, Australia. tlinnane@cmbm.com.au
Abstract
In this paper, we report results obtained from a continuing clinical trial on the effect of coenzyme Q10 (CoQ10) administration on human vastus lateralis (quadriceps) skeletal muscle. Muscle samples, obtained from aged individuals receiving placebo or CoQ10 supplementation (300mg per day for four weeks prior to hip replacement surgery) were analysed for changes in gene and protein expression and in muscle fibre type composition. Microarray analysis (Affymetrix U95A human oligonucleotide array) using a change in gene expression of 1.8-fold or greater as a cutoff point, demonstrated that a total of 115 genes were differentially expressed in six subject comparisons. In the CoQ10-treated subjects, 47 genes were up-regulated and 68 down-regulated in comparison with placebo-treated subjects. Restriction fragment differential display analysis showed that over 600 fragments were differentially expressed using a 2.0-fold or greater change in expression as a cutoff point. Proteome analysis revealed that, of the high abundance muscle proteins detected (2,086 +/- 115), the expression of 174 proteins was induced by CoQ10 while 77 proteins were repressed by CoQ10 supplementation. Muscle fibre types were also affected by CoQ10 treatment; CoQ10-treated individuals showed a lower proportion of type I (slow twitch) fibres and a higher proportion of type IIb (fast twitch) fibres, compared to age-matched placebo-treated subjects.The data suggests that CoQ10 treatment can act to influence the fibre type composition towards the fibre type profile generally found in younger individuals. Our results led us to the conclusion that coenzyme Q10 is a gene regulator and consequently has wide-ranging effects on over-all tissue metabolism. We develop a comprehensive hypothesis that CoQ10 plays a major role in the determination of membrane potential of many, if not all, sub-cellular membrane systems and that H2O2 arising from the activities of CoQ10 acts as a second messenger for the modulation of gene expression and cellular metabolism.
COQ10 & Muscle Fiber Changes?
I briefly considered Co-Q10 for Mass Pro Synthagen, ultimately rejecting it. NOT b/c it doesnt impart some benefits (it's used clinically in Japan for example, with respect to treatment for congestive heart failure, etc.).
The practical reality is though, that Co-Q10 is much like many other supps that look great in the literature, yet don't measure up in the real world (i.e. CLA, etc.).
The benefits in cellular energy metabolism Co-Q10 impart are what athletes seek. This study while interesting, overlooks one important fact: Training ALONE can change muscle fiber type, depending upon whether your training is slow/fast twitch dominant. In other words, the body will adapt by changing muscle fiber composition to reflect the training demand.
Synthagen excels at stoking cellular energy metabolism via its use of other, more potent nutraceuticals. More importantly, it re-generates cellular energy currency (primarily ATP) for moreso than Co-Q10 ever could.
Still, for those of you on statins/know others on statins - know this: They deplete Co-Q10. In that instance, Co-Q10 supplementation can help...
The practical reality is though, that Co-Q10 is much like many other supps that look great in the literature, yet don't measure up in the real world (i.e. CLA, etc.).
The benefits in cellular energy metabolism Co-Q10 impart are what athletes seek. This study while interesting, overlooks one important fact: Training ALONE can change muscle fiber type, depending upon whether your training is slow/fast twitch dominant. In other words, the body will adapt by changing muscle fiber composition to reflect the training demand.
Synthagen excels at stoking cellular energy metabolism via its use of other, more potent nutraceuticals. More importantly, it re-generates cellular energy currency (primarily ATP) for moreso than Co-Q10 ever could.
Still, for those of you on statins/know others on statins - know this: They deplete Co-Q10. In that instance, Co-Q10 supplementation can help...
Was there anything you stocked before which in your opinion worked but just didnt sell at all?askmass wrote:We stocked a high end medical issue CoQ10 in the mid 90's for a couple years here at MASS.
Ultimately, we found it got next to no positive feedback from the muscle building crowd and we therefore dropped our distribution.
It does have specific medical uses IMO, for the record.
Well, there have been a few items we have stuck with that initially didn't sell gangbusters. Alkaplex is the prime example that comes to mind. We knew the great value it held, both in results and in cost effectiveness, but it didn't have any "HEY WOW" sizzle factor, especially in the prohormone era.DaCookie wrote:Was there anything you stocked before which in your opinion worked but just didnt sell at all?askmass wrote:We stocked a high end medical issue CoQ10 in the mid 90's for a couple years here at MASS.
Ultimately, we found it got next to no positive feedback from the muscle building crowd and we therefore dropped our distribution.
It does have specific medical uses IMO, for the record.
We stuck with it though, and continued extolling it's virtues until slowly but surely it earned a real foothold among our crowd.
Then, in time it really caught on big, to the point we were stunned how much was being snapped up given it's very slow start.
I think word of mouth as much as anything made it become such a big hit item for us.
But, based on initial sales alone, most places surely would have ran a clearance after a few months and dropped it cold.