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January 2009 from Rutgers University




Research article summary (published 4 Jan 2009):

20-Hydroxyecdysone decreases weight and hyperglycemia in a diet-induced obesity mice model.

Full Abstract
The steroid hormone 20-hydroxyecdysone (20HE) is an essential signaling molecule that modulates molting response in insects and may function as a putative anabolic factor in vertebrate animals, although no mammalian 20HE receptor has been identified. Here we show that in H4IIE cell culture, 20HE treatment decreased expression of phosphoenolpyruvate carboxykinase (PEPCK) and glucose-6-phosphatase (G6Pase), reduced glucose production, and induced Akt2 phosphorylation sensitive to the phosphoinositide-3 kinase pathway-specific inhibitor LY-294002. Daily oral administration of 20HE (10 mg/kg for 13 wk) ameliorated obesity and insulin resistance in C57BL/6J mice fed a high-fat diet and produced a significant decrease of body weight gain and body fat mass compared with nontreated animals as demonstrated by dual-energy X-ray absorptiometry analysis. In addition, plasma insulin levels and glucose tolerance were significantly lowered by 20HE treatment. These changes were accompanied by the reduced hepatic expression of PEPCK and G6Pase and increased adiponectin production by visceral fat tissue. These studies demonstrate the anti-obesity and anti-diabetic effects of 20HE and begin to elucidate its putative cellular targets both in vitro and in vivo.

I have heard from a number of trainers who cite anti-diabetic comments re KA.

MORE... (Credit Ergolog.com)

Ecdysteroids curb growth of fat tissue

More plus factors for the ecdysteroids: the steroid compounds in spinach-type plants not only have an anabolic effect, but also curb the growth of fat layers. Researchers at Rutgers University will soon publish the results of a study which offers evidence that ecdysterone prevents overfed mice from getting fat.

The same researchers have already published an article in which they showed that ecdysterone makes the muscle cells of rats grow faster. Ecdysterone also made the animals stronger. Hungarian researchers confirmed the results a few months later. According to their animal study, ecdysterone has an anabolic effect in slow muscle fibres.

In their latest publication the Americans examine whether ecdysterone is a suitable model for developing a new medicine for obesity and diabetes 2. That’s why they fed mice a diet that consisted of sixty percent fat for the experiment. [HF] The mice in the control group were given a diet containing only ten percent fat. [LF] Mice on this level of diet do not become fat.

Half of the high-fat diet mice were given a daily dose of 10 mg ecdysterone per kilo bodyweight. Orally. The experiment lasted thirteen weeks.

Adiponectin is a protein that is secreted by healthy fat cells sensitive to insulin. Adiponectin suppresses appetite and heightens the effect of insulin. And the other way round, if the cells’ insulin performance declines, the secretion of adiponectin also goes down. It looks as though ecdysterone helps reverse this process in mice that are putting on weight.

As the mice get fatter, the concentration of glucose in their blood rises. Apparently they can’t make enough insulin to process the glucose, or their insulin receptors are not working so well. But if the fat mice are also given ecdysterone this doesn’t happen.

TAKE AWAY: Kre-Anabolyn improves insulin function/glucose disposal leading to less fat gain during overfeeding. Exactly why we position where it is in The Blueprint. Add to this the same fuctional properties exhibited by 4-hydroxyisoleucine and you can see why the formula was crafted the way it was...