You guys are in for a real treat with this...
MASS has listed the precise amounts of CurcuClear Curcumin Concentrate as well as the Verified Full Spectrum Rhodiola per cap (I suspect) for a reason - it's LOADED.
Look at the Rhodiola for example. This material we're using is the best of the best, and included in a mg amount per cap = to the manufacturer's product. Their's normally retails for $26 for that ingredient alone, never mind the supporting cast TQ brings to the table. When you buy the 3 bottle + 1 free special, TQ comes down to just $33/bottle!
You're also getting truly synergistic ingredients. For example, Rhodiola has been shown to
increase levels of serotonin in the brain, and it helps
increase the permeability of the blood-brain barrier, which allows precursors to serotonin (i.e. 5-HTP) and other neurotransmitters to cross into the brain more easily. R. rosea also increases the permeability of the blood-brain barrier to precursors of dopamine and serotonin [1 , 2 , 3] and improves cerebral circulation. [4]
(1) Kurkin VA, Zapesochnaya GG. Chemical composition and pharmacological properties of Rhodiola rosea . Chem Pharm J . 1986;20(10):1231-1244.
(2) Petkov VD, Yonkov D, Mosharoff A, et al. Effects of alcohol aqueous extract from Rhodiola rosea L. roots on learning and memory. Acta Physiol Pharmacol Bulg . 1986;12(1):3-16.
(3) Saratikov A, Marina TF, Fisanova LL. Effect of golden root extract on processes of serotonin synthesis in CNS. J Biol Sci . 1978;6:142.
(4) Pogorelyi VE, Makarova LM. Rhodiola rosea extract for prophylaxis of ischemic cerebral circulation disorder [in Russian]. Eksp Klin Farmakol . 2002;65(4):19-22.
The CurcuClear Concentrate is likewise strategically dosed. You don't want TOO much Curcumin, given it can and does convert to a PRO-oxidant and causes damage. For example, when comparing 500mg curcumin against 6g curcumin, the anti-oxidative potential of the two does not significantly differ; if anything, 500mg curcumin seems superior due to insignificantly higher AUC of the increase in anti-oxidant abilities as measured by ORAC.[5] This is thought to be due to a possible pro-oxidant effect of curcumin at higher dosages, seen with other anti-oxidants (i.e. NAC) .[6][7]
(5) Akazawa N, et al. Curcumin ingestion and exercise training improve vascular endothelial function in postmenopausal women. Nutr Res. (2012)
(6) Ciardi C, et al. Food additives such as sodium sulphite, sodium benzoate and curcumin inhibit leptin release in lipopolysaccharide-treated murine adipocytes in vitro. Br J Nutr. (2012)
(7) Pongchaidecha A, et al. Effects of curcuminoid supplement on cardiac autonomic status in high-fat-induced obese rats. Nutrition. (2009)
The reason we went with a full spectrum extract? Curcumin contains
four curcuminoids, a curcuminoid being defined as a molecule with two ferulic acid moieties bound together. At least one study has looked at the effects of each ingredient in isolation and the combination, and in regards to its beneficial effects the four curcuminoids show synergism with each other.[8]
(8) Chemistry and biological activities of C. longa
Astaxanthin? Natural sourced and more in there than any other product I'm aware of. In there for a reason too, given it's benefits (many of which potentiate Curcumin's) last a LONG time. It has a plasma elimination half-life of 52 hours with a standard deviation of 40.[9]
(9) Coral-Hinostroza GN, et al. Plasma appearance of unesterified astaxanthin geometrical E/Z and optical R/S isomers in men given single doses of a mixture of optical 3 and 3'R/S isomers of astaxanthin fatty acyl diesters. Comp Biochem Physiol C Toxicol Pharmacol. (2004) Iwamoto T, et al. Inhibition of low-density lipoprotein oxidation by astaxanthin. J Atheroscler Thromb. (2000)
